Investigator: William T. Phillips, MD

Co-Investigators: Vibhudutta Awasthi, PhD and Beth Goins, PhD

Abstract:

To study the circulation kinetics of freeze-dried platelets (FDP) in normal rabbits and to investigate the effect of re-injection of human freeze-dried platelets (thrombosomes).

There were no observed differences in accumulation of endogenous platelets and FDPs in other tissues. It is clear that accumulation in blood, liver and spleen were substantial among endogenous fresh platelets and various FDPs. The pattern was identical when the data was registered in per organ basis. It is important to note that the regardless of the source of freeze-dried platelets, biodistribution of various FDPs in rabbits was remarkably similar.