Bodevet

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So far Bodevet has created 14 blog entries.

Elephant disease causes death by hemorrhage… Lyophilized platelets may help!

Authors: Jennifer C. Kishbaugh, DVM, Marc T. Valitutto, VMD, Janelle E. Over, MS, Dawn M. Zimmerman, DVM, MS, Lauren L. Howard, DVM, Dennis L. Schmitt, DCM, PhD, Carlos R. Sanchez, DVM, Suzan Murray, DVM. The in-human care population of elephants is plagued by an endotheliotropic herpes virus that attacks young elephants and causes an acute [...]

By |2019-05-08T11:50:26+00:00May 8th, 2019|Uncategorized|0 Comments

Safety Evaluation of Lyophilized Canine Platelets in a Model of CABG

Authors: Todd M. Getz, PhD, Anne S.Hale, DVM, Arthur P. Bode, PhD, Mark D. Johnson, MS, G. Michael Fitzpatrick, PhD Project Overview: Cellphire evaluated the safety of Lyophilized Canine Platelets (LCP) in comparison to Liquid Stored Canine Platelets following intravenous administration in a model of on-pump coronary artery bypass graft (CABG) in the canine. Learn [...]

By |2019-05-08T11:41:03+00:00May 8th, 2019|Uncategorized|0 Comments

Wound-healing properties of trehalose-stabilized freeze-dried outdated platelets

Authors: Ruth Sum,* Sarah Hager,* Giorgio Pietramaggiori, Dennis P. Orgill, Josh Dee, Alan Rudolph, Cindy Orser, G. Michael Fitzpatrick, and David Ho Project Overview: Wounds treated with multiple doses of VEGF and a single dose of freeze-dried platelets reached 90% closure faster than wounds left untreated. A single administration of trehalose lyophilized and reconstituted platelet [...]

By |2019-05-08T11:32:09+00:00May 8th, 2019|Uncategorized|0 Comments

Trehalose Stabilized Freeze Dried Human Platelets, Thrombosomes®, Persist in Circulation 24 Hours After Infusion and Are Non-Immunogenic In New Zealand White Rabbits

Authors: Vibhudutta Awasthi, Josh Dee, Mike Fitzpatrick, Anna Koh, Richard Cliff, Giora Feuerstein Project Overview: Thrombosomes®, a human platelet derived hemostatic agent, (PDHA) is being developed to meet a critical unmet medical need, e.g. a safe PDHA that restores hemostasis in patients with a coagulopathy that does not respond to standard treatment Learn More [...]

By |2019-05-08T11:26:17+00:00May 8th, 2019|Uncategorized|0 Comments

Trehalose Stabilized Freeze Dried Human Platelets, Thrombosomes®, Reduce Blood Loss in Thromboctopenic Rabbit Ear Bleed Model By As Much As 89.5%

Authors: Vibhudutta Awasthi, Josh Dee, Mike Fitzpatrick, Anna Koh, Richard Cliff, Giora Feuerstein Project Overview: Thrombosomes®, are lyophilized derivative of human platelets, is being developed for treatment of civilian or military combat related trauma and shock conditions associated with life-threatening bleeding Learn More

By |2019-05-08T11:23:17+00:00May 8th, 2019|Uncategorized|0 Comments

Trehalose Stabilized Freeze Dried Human Platelets, Thrombosomes®, Express Surface Markers, Thromboelastogram (TEG) Values and Size Distribution Similar To Two To Three Day Old Stored Platelets

Authors: Josh Dee, Mike Fitzpatrick, Anna Koh, Richard Cliff, Giora Feuerstein Project Overview: Thrombosomes® is lyophilized derivative of human platelets developed as a hemostatic product for treatment of civilian as well as combat related trauma and shock conditions associated with life-threatening bleeding. Thrombosomes is produced by a proprietary process that includes Trehalose, other carbohydrates, and [...]

By |2019-05-08T11:18:36+00:00May 8th, 2019|Uncategorized|0 Comments

Dried platelets in a Swine Model of Liver Injury

Authors: Kenji Inaba,* Galinos Barmparas,* Peter Rhee,† Bernardino C. Branco,‡ Michael Fitzpatrick,§ Obi T. Okoye,* and Demetrios Demetriades* Project Overview: Lyophilization may facilitate production of a safe, portable, easily storable, and transportable source of platelets for bleeding patients. The objective of this study was to examine the impact of lyophilized human and porcine platelets in [...]

By |2019-05-08T11:11:34+00:00May 8th, 2019|Uncategorized|0 Comments

Assessment of platelet growth factors in supernatants from rehydrated freeze-dried equine platelets and their effects on fibroblasts in vitro

Authors: Fern Tablin, VMD, PhD; Naomi J. Walker, BA; Sara E. Hogle, DVM; Suzanne M. Pratt, DVM; Jeffrey W. Norris, PhD Objective: To determine whether platelet growth factors are preserved in supernatants obtained from rehydrated trehalose-stabilized, freeze-dried (lyophilized) equine latelets and whether those growth factors stimulate fibroblast proliferation and migration and enhance fibroblast-associated contraction in [...]

By |2019-05-08T10:58:24+00:00May 8th, 2019|Uncategorized|0 Comments
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