Safety Evaluation of Lyophilized Canine Platelets in a Model of CABG

Authors: Todd M. Getz, PhD, Anne S.Hale, DVM, Arthur P. Bode, PhD, Mark D. Johnson, MS, G. Michael Fitzpatrick, PhD Project Overview: Cellphire evaluated the safety of Lyophilized Canine Platelets (LCP) in comparison to Liquid Stored Canine Platelets following intravenous administration in a model of on-pump coronary artery bypass graft (CABG) in the canine. Learn [...]

By |2019-07-20T10:33:19+00:00May 8th, 2019|Research|0 Comments

Trehalose Stabilized Freeze Dried Human Platelets, Thrombosomes®, Persist in Circulation 24 Hours After Infusion and Are Non-Immunogenic In New Zealand White Rabbits

Authors: Vibhudutta Awasthi, Josh Dee, Mike Fitzpatrick, Anna Koh, Richard Cliff, Giora Feuerstein Project Overview: Thrombosomes®, a human platelet derived hemostatic agent, (PDHA) is being developed to meet a critical unmet medical need, e.g. a safe PDHA that restores hemostasis in patients with a coagulopathy that does not respond to standard treatment Learn More [...]

By |2019-07-20T10:35:58+00:00May 8th, 2019|Research|0 Comments

Trehalose Stabilized Freeze Dried Human Platelets, Thrombosomes®, Reduce Blood Loss in Thromboctopenic Rabbit Ear Bleed Model By As Much As 89.5%

Authors: Vibhudutta Awasthi, Josh Dee, Mike Fitzpatrick, Anna Koh, Richard Cliff, Giora Feuerstein Project Overview: Thrombosomes®, are lyophilized derivative of human platelets, is being developed for treatment of civilian or military combat related trauma and shock conditions associated with life-threatening bleeding Learn More

By |2019-07-20T10:40:16+00:00May 8th, 2019|Research|0 Comments

Trehalose Stabilized Freeze Dried Human Platelets, Thrombosomes®, Express Surface Markers, Thromboelastogram (TEG) Values and Size Distribution Similar To Two To Three Day Old Stored Platelets

Authors: Josh Dee, Mike Fitzpatrick, Anna Koh, Richard Cliff, Giora Feuerstein Project Overview: Thrombosomes® is lyophilized derivative of human platelets developed as a hemostatic product for treatment of civilian as well as combat related trauma and shock conditions associated with life-threatening bleeding. Thrombosomes is produced by a proprietary process that includes Trehalose, other carbohydrates, and [...]

By |2019-07-20T10:38:37+00:00May 8th, 2019|Research|0 Comments

Temporal Growth Factor Release from Platelet-Rich Plasma, Trehalose Lyophilized Platelets, and Bone Marrow Aspirate and Their Effect on Tendon and Ligament Gene Expression

Authors: Taralyn McCarrel and Lisa Fortier Abstract: Platelet-rich plasma (PRP) has generated substantial interest for tendon and ligament regeneration because of the high concentrations of growth factors in platelet a-granules. This study compared the temporal release of growth factors from bone marrowaspirate (BMA), PRP, and lyophilized platelet product (PP), and measured their effects on tendon [...]

By |2019-07-17T18:07:21+00:00May 8th, 2019|Research|0 Comments

Trehalose lyophilized platelets for wound healing

Authors: Giorgio Pietramaggiori, MD; Arja Kaipainen, MD, PhD; David Ho, PhD; Cindy Orser, PhD; Walter Pebley, PE; Alan Rudolph, PhD, MBA; Dennis P. Orgill, MD, PhD Abstract: Fresh platelet preparations are utilized to treat a wide variety of wounds, although storage limitations and mixed results have hampered their clinical use. We hypothesized that concentrated lyophilized [...]

By |2019-07-17T18:07:57+00:00May 8th, 2019|Research|0 Comments

Single Dose Toxicity Study Of Canine Thrombosomes™ In Dogs Followed By A 14-Day Observation Period

Study Director: Jonathan C. White, M.S.A. Abstract: This study was conducted for Cellphire, Inc., to evaluate the safety of the test article, Canine Thrombosomes™, following a single infusion dose of 10x the native platelet protein per animal (10x) or 3 doses of 1x the native platelet protein per animal (3x). Two treatment groups of six [...]

By |2019-07-17T18:08:13+00:00May 8th, 2019|Research|0 Comments

Clinical Development of Stabilized Platelets for In-fusible Clinical Applications

Investigator: William T. Phillips, MD Co-Investigators: Vibhudutta Awasthi, PhD and Beth Goins, PhD Abstract: To study the circulation kinetics of freeze-dried platelets (FDP) in normal rabbits and to investigate the effect of re-injection of human freeze-dried platelets (thrombosomes). There were no observed differences in accumulation of endogenous platelets and FDPs in other tissues. It is [...]

By |2019-07-17T18:46:08+00:00May 8th, 2019|Research|0 Comments
Call Now Button