Trehalose Stabilized Freeze Dried Human Platelets, Thrombosomes®, Express Surface Markers, Thromboelastogram (TEG) Values and Size Distribution Similar To Two To Three Day Old Stored Platelets

By |May 8th, 2019|Categories: Uncategorized|

Authors: Josh Dee, Mike Fitzpatrick, Anna Koh, Richard Cliff, Giora Feuerstein Project Overview: Thrombosomes® is lyophilized derivative of human platelets developed as a hemostatic product for treatment of civilian as well as combat related trauma and shock conditions associated with [...]

Dried platelets in a Swine Model of Liver Injury

By |May 8th, 2019|Categories: Uncategorized|

Authors: Kenji Inaba,* Galinos Barmparas,* Peter Rhee,† Bernardino C. Branco,‡ Michael Fitzpatrick,§ Obi T. Okoye,* and Demetrios Demetriades* Project Overview: Lyophilization may facilitate production of a safe, portable, easily storable, and transportable source of platelets for bleeding patients. The objective [...]

Assessment of platelet growth factors in supernatants from rehydrated freeze-dried equine platelets and their effects on fibroblasts in vitro

By |May 8th, 2019|Categories: Uncategorized|

Authors: Fern Tablin, VMD, PhD; Naomi J. Walker, BA; Sara E. Hogle, DVM; Suzanne M. Pratt, DVM; Jeffrey W. Norris, PhD Objective: To determine whether platelet growth factors are preserved in supernatants obtained from rehydrated trehalose-stabilized, freeze-dried (lyophilized) equine latelets [...]

Temporal Growth Factor Release from Platelet-Rich Plasma, Trehalose Lyophilized Platelets, and Bone Marrow Aspirate and Their Effect on Tendon and Ligament Gene Expression

By |May 8th, 2019|Categories: Uncategorized|

Authors: Taralyn McCarrel and Lisa Fortier Abstract: Platelet-rich plasma (PRP) has generated substantial interest for tendon and ligament regeneration because of the high concentrations of growth factors in platelet a-granules. This study compared the temporal release of growth factors from [...]

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